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Reference: 
Barford, D.; Hu, S-H. and
Johnson, L. N., J. Mol. Biol., 1991, 218, 233. 
The phosphorylated (P) form and non-phospohrylated (Non-P) form have different tertiary structures, even in parts of the structure distal to the phosphorylation site at Ser14. The active-site of the enzyme contains pyridoxal phosphate (PLP) as a co-factor.