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Crystal Structure of α-Hemolysin from Staphylococcus aureus

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2° Structural Features
3° Structural Features

4° Structural Features

Other Features

Gouaux, E.,  J. Struct. Biol., 1998, 121, 110-122.

α-Hemolysin is a protein toxin from the bacterial species Staphylococcus aureus.  The single subunit assembles on the membranes of blood cells (erythrocytes, platelets, monocytes...) as a heptamer to form a transmembrane pore of diameter ~20 Å, resulting in cell lysis.  The key membrane spanning domain of the complex is a 14-stranded antiparallel β-barrel formed from a single β-hairpin from each of the subunits.